Neuropilin: From Nervous System to Vascular and Tumor Biology

Neuropilin: From Nervous System to Vascular and Tumor Biology (Advances in Experimental Medicine and Biology, 515)

Cell adhesion is one of the most important properties controlling embryonic development. Extremely precise cell-cell contacts are established according to the nature of adhesion molecules that are expressed on the cell surface. The identificaÂ tion of several families of adhesion molecules, well conserved throughout evoluÂ tion, has been the basis of a considerable amount of work over the past 20 years that contributed to establish functions of cell adhesion in almost all organs. Nowadays, cell adhesion molecules are not just considered as cellular glue but are thought to play critical roles in cell signaling. Their ability to influence cell proliferation, miÂ gration, or differentiation depends on both cell surface adhesion properties and actiÂ vation of intracellular pathways. The next challenge will be to understand how these molecules interact with each other to ensure specific functions in the morphogenÂ esis of very sophisticated systems. Indeed, by exploring the cellular and molecular mechanisms of nervous system development, the group of H. Fujisawa in Japan identified in 1987 an adhesion molecule, neuropilin, highly expressed in the neuroÂ pile of amphibian optic tectum. Ten years later, two groups discovered that neuropilin is a receptor for guidance signals of the semaphorin family. Axon guidance is a critical step during brain development and the mechanisms ensuring growth cone navigation are beginning to be well understood. The semaphorins are bifunctional signals defining permissive or inhibitory pathways sensed by the growth cone.
Country USA
Brand Springer
Manufacturer Springer
Binding Hardcover
ItemPartNumber Refer to Sapnet.
UnitCount 1
Format Illustrated
EANs 9780306474163
ReleaseDate 0000-00-00

Country	USA
Brand	Springer
Manufacturer	Springer
Binding	Hardcover
ItemPartNumber	Refer to Sapnet.
UnitCount	1
Format	Illustrated
EANs	9780306474163
ReleaseDate	0000-00-00

Neuropilin: From Nervous System to Vascular and Tumor Biology (Advances in Experimental Medicine and Biology, 515)

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