The Use of Human Cells for the Evaluation of Risk from

The Use of Human Cells for the Evaluation of Risk from Physical and Chemical Agents

In this volume are collected 30 papers, 9 round table discusÂ sions and 11 communications presented at the ASI Course on "The use of human cells for the evaluation of risk from physical and chemical agents", sponsored by NATO and organized by ENEA. The aim of the Course was to present different scientific apÂ proaches and technical advices in order to get dose-effect relationÂ ships which are the basis for risk evaluation. The scientific backÂ ground which is behind this approach was extensively discussed. Emphasis has been given to the use of human cells or human data in order to attempt to have a correct and realistic evaluation of the damage in humans. There are many criticisms on the use of animal data for human risk evaluation because of differences between species and between strains within the same species: differences in metabolism, activaÂ tion processes and DNA repair ability makes uncertain the extrapolaÂ tion of animal data to humans. Also data obtained using specific strains or highly inbred strains in order to reduce the variance are not applicable due to the heterogeneity of the human population connected with individual responses. In this respect only the use of human cells enable us to detect the individual variability and to identify sensitive subpopuÂ lations that would be at greater risk. My appreciation to Pieranita and Alberto Castellani for the asÂ sistance during the meeting and to Giuseppe Biondi for his help in some of the editorial work.
Country USA
Brand Springer
Manufacturer Springer
Binding Paperback
ItemPartNumber 132 black & white illustrations, biograp
ReleaseDate 2013-04-15
UnitCount 1
EANs 9781475711196

Country	USA
Brand	Springer
Manufacturer	Springer
Binding	Paperback
ItemPartNumber	132 black & white illustrations, biograp
ReleaseDate	2013-04-15
UnitCount	1
EANs	9781475711196

The Use of Human Cells for the Evaluation of Risk from Physical and Chemical Agents

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