Carbona stain devils are individually formulated, stain removal instructions may change from formula to formula. Follow the directions printed on the label of the bottle you are using. Some are instant, some are not. While the appropriate stain devils formula should completely remove your stain, the time required may vary from immediately to several minutes or more. Combination stains, this can make stain removal a bit more complicated and may require more than one stain devils formula to remove it completely. But if you value your garment, it's worth the extra time.